{"id":421,"date":"2017-07-28T15:09:48","date_gmt":"2017-07-28T22:09:48","guid":{"rendered":"https:\/\/www.cattitudebehavior.com\/?p=421"},"modified":"2020-10-26T12:50:16","modified_gmt":"2020-10-26T19:50:16","slug":"feline-cognitive-dysfunction","status":"publish","type":"post","link":"https:\/\/www.cattitudebehavior.com\/index.php\/2017\/07\/28\/feline-cognitive-dysfunction\/","title":{"rendered":"Feline Cognitive Dysfunction"},"content":{"rendered":"<p><span style=\"font-family: georgia,palatino,serif;\"><em>Published August 21, 2012, <strong>The IAABC Journal (International Association Of Animal Behavioral Consultants)<\/strong><\/em><\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">The joys of keeping our cats indoors with plenty of environmental enrichment, good food, health care and an enormous amount of love and respect are all well-documented: besides having a happier and healthier companion, those fur-kids are living longer. Much longer. Indoor cats living over 20 years simply aren\u2019t uncommon any more.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">However, as with humans, our pets are also getting ills that can come with age, including neurological conditions. One such ailment is cognitive dysfunction syndrome (CDS), which is characterized by a set of changes in behavior that can be upsetting to see. Although CDS is well known in dogs, some vets feel that cats don\u2019t get such a syndrome, that it is old age in itself.<\/span><\/p>\n<p><span style=\"font-size: 18pt;\"><strong><span style=\"font-family: georgia,palatino,serif;\">The debate: does CDS exist in cats?<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Dr. Ross Babcock, a veterinarian in Phoenix for over 48 years says, \u201cI don\u2019t see it in the exam room. Cats age. Their behavior changes, but it\u2019s almost as though the behavior is a result of not having the ability to back things up. There are clear syndromes in dogs, but we don\u2019t see it in cats.\u201d<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Many vets and experienced behaviorists strongly disagree. \u201cFew vets recognize cognitive dysfunction because of where the money is\u201d. according to Beth Edelman, feline behaviorist for over 15 years and former cat columnist for the New York Post. \u201cThey recognize it in dogs,\u201d she goes on, \u201cbecause a lot of health research is driven by the purebred world, and the dog fancy represents a much larger proportion of the dog world than the cat fanciers of the world do. Good studies do show altered behavior in older cats that differs from normal aging. Aimless wandering; night vocalizing and wakening;, irritability; aggression; disorientation\u2014not normal with aging. The difference is neuro-degenerative, and that\u2019s nothing to do with old age.\u201d<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">We know more about dog CDS than cat CDS, certainly. In an <span style=\"color: #0000ff;\"><a href=\"https:\/\/www.psychologytoday.com\/blog\/minds-animals\/200907\/science-and-the-domestic-cat?destination=blog\/minds-animals\/200907\/science-and-the-domestic-cat\" target=\"_blank\" rel=\"noopener noreferrer\">article for Psychology Today<\/a><\/span>, canine cognition researcher Dr. Alexandra Horowitz wrote: \u2018In the last decade, the study of dog cognition has blossomed: there are now many research groups, in the U.S. and especially abroad, committed to testing the behavior of pet dogs\u2026 But research into \u201ccat cognition\u201d has lagged behind.\u2019<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Why might this be? Dr. Horowitz has the following suggestion:<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">\u201cWe feel that we already know what cats can do. Cats are padding along in some 30% of American households; they don\u2019t feel exotic. There is no dearth of cat behavior books; every cat owner thinks himself an expert in the species\u2019 behavior (and probably is reasonably expert at least at describing his own cat\u2019s behavior). And among the things we \u2018know\u2019 about cats is another blow against their likelihood of being studied: cats are seen as \u2018independent\u2019 and unresponsive to owners. The impetus of the field of dog cognition rests largely on the dogs\u2019 successes at \u2018social cognitive\u2019 tasks: those predicated on their being reliably responsive to and interactive with humans. Some physiological features of cats also handicap them as behavioral research subjects: their facial features are less flexuous, less expressive, than the dog with his protruding snout, wide mouth, and often enormous, mobile ears.\u201d<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Dr. Babcock has a simpler answer: \u201cThere\u2019s no money in cats. Dogs are genetically closer to humans than cats are.\u201d<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">This debate begs the questions: what is the difference between old age and real CDS in cats? And, have those researchers and vets who are taking feline cognitive dysfunction seriously found ways to manage the condition? Are cats being managed as well as dogs with cognitive dysfunction?<\/span><\/p>\n<p><span style=\"font-size: 18pt;\"><strong><span style=\"font-family: georgia,palatino,serif;\">Different types of cognitive dysfunction in cats<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">To answer these questions, we first need to understand the difference between cognitive dysfunction syndrome and other degenerative neurological conditions in cats, like dementia. It\u2019s easy to get confused.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Dementia is a progressive loss of cognition or mental faculties due to brain tissue damage. It\u2019s associated with aging, but younger cats can get it due to other causes, such as head trauma. We know heredity plays a role, but we don\u2019t completely understand the causes. In humans, Alzheimer\u2019s disease is a type of dementia.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">CDS is a kind of mental health disorder, involving degeneration and loss of nerve cells in the brain, resulting in behavioral changes. Here too, age is the greatest risk factor, but it\u2019s not the only one. Cats as young as eight (48, in human terms) can show symptoms.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">If, as <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/17617164\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #0000ff;\">Dr. Danielle Gunn-Moore<\/span><\/a> of the University of Edinburgh\u2019s Royal School of Veterinary Studies, says, \u201cTwenty-eight percent of pet cats aged 11to14 years develop at least one old age\u2013related behavior problem and this increases to more than 50% for cats over 15,\u201d then how do you know if Finchley is just getting older, or has CDS?<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">\u201cIt isn\u2019t easy\u201d admits Dr. Marc Schmidt, veterinarian in San Tan Valley, Arizona. \u201cWe make sure it\u2019s diagnosis by exclusion\u2014that it isn\u2019t medical, that the cat\u2019s behavior is out of character, such as staring off into space, getting confused.\u201d Aren\u2019t those also symptoms of old age? \u201cYes. In people, they have a more defined and refined way of judging, but in cats, we haven\u2019t gotten that far. We can\u2019t test our patients the way doctors can with people.\u201d<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">That\u2019s the bottom line: thus far, nobody can know for sure just what is wrong with your cat. Dr. Scott Plummer, of the Veterinary Neurology Center in Arizona, is succinct: \u201cAging and feline cognitive dysfunction are impossible to differentiate at this time.\u201d<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">The causes of CDS are also not fully understood, but several possible reasons are being explored. For example, the environment has been implicated. \u201cAir pollution and excessive noise may predispose to\u2026cognitive dysfunction, over time,\u201d says veterinary nursing lecturer <a href=\"http:\/\/dx.doi.org\/10.1016\/j.jveb.2012.08.001\" target=\"_blank\" rel=\"noopener noreferrer\"><span style=\"color: #0000ff;\">Julie Cory<\/span><\/a><span style=\"color: #0000ff;\">,<\/span> of the College of Animal Welfare in Huntington, England. \u201cNeuro-inflammation associated [with these things] can lead to oxidative damage and the development of amyloid plaque [the buildup of a kind of protein found in the CDS brain].\u201d<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Abnormal behavior that looks like CDS can have many causes, explains <span style=\"color: #0000ff;\"><a href=\"http:\/\/www.vet.cornell.edu\/fhc\/Health_Information\/CognitiveDysfunction.cfm\" target=\"_blank\" rel=\"noopener noreferrer\">Dr. Alexander de Lahunta<\/a><\/span>, emeritus professor of anatomy at Cornell College of Veterinary Medicine. Tissue inflammation, hyperthyroidism, kidney disease, tumors, trauma, or metabolic conditions can all be responsible. \u201cIf magnetic resonance imaging (MRI) and analysis of cerebrospinal fluid fail to reveal a physical problem in the brain, then the problem is something that is probably best treated by an animal behaviorist.\u201d<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">\u201cDiagnosis by exclusion,\u201d meanwhile, is all we have to go on; what\u2019s left may be CDS, or it may be just old age.<\/span><\/p>\n<p><span style=\"font-size: 18pt;\"><strong><span style=\"font-family: georgia,palatino,serif;\">How can we identify the symptoms?<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">There are, however, symptoms that pet parents and behaviorists can be on the lookout for. There\u2019s also a context: a symptom or two may not be CDS but age; more than that should be checked out. For example:<\/span><\/p>\n<ul>\n<li><span style=\"font-family: georgia,palatino,serif;\">Aimlessness: Finchley can wander in a way he didn\u2019t before, with a less purposeful gait. He may saunter to places he used to avoid. You could find him staring, but it\u2019s not his usual \u201cDon\u2019t you see that wee speck?\u201d look.<\/span><\/li>\n<li><span style=\"font-family: georgia,palatino,serif;\">Changes in memory. He forgets where his box or food bowl is, and his usual response\u2014to his name, to a firm but quiet \u201cNo\u201d or to \u201cDinner!\u201d\u2014isn\u2019t the same, or he no longer has one. You know his learning curve; but now there doesn\u2019t seem to be one.<\/span><\/li>\n<li><span style=\"font-family: georgia,palatino,serif;\">Crying, with a plaintive or anxious tone.<\/span><\/li>\n<li><span style=\"font-family: georgia,palatino,serif;\">He\u2019s become cantankerous, even aggressive, and it isn\u2019t because of physical discomfort.<\/span><\/li>\n<li><span style=\"font-family: georgia,palatino,serif;\">His waking and sleeping habits are different; his cycle has changed.<\/span><\/li>\n<li><span style=\"font-family: georgia,palatino,serif;\">Activities that used to grab his attention, such as playtime, aren\u2019t interesting anymore.<\/span><\/li>\n<li><span style=\"font-family: georgia,palatino,serif;\">Appetite problems. He\u2019s not bothered with food, even his favorite treats. There\u2019s less gusto when he eats.<\/span><\/li>\n<li><span style=\"font-family: georgia,palatino,serif;\">He can become needy, especially at night. Conversely, he can act as if he doesn\u2019t know someone he knew well.<\/span><\/li>\n<li><span style=\"font-family: georgia,palatino,serif;\">He doesn\u2019t groom himself, such as his coat, eyes or ears as carefully as he used to.<\/span><\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">There\u2019s another symptom, which is harder to define. I\u2019ve seen it in my 16-year-old, Grace. She\u2019s somehow less focused, even a little faraway. She was never a \u201cslow-blinker,\u201d but now she looks away sooner than she used to. It breaks my heart.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">There\u2019s no cure for CDS. Not for humans, not for other animals. But there are things we can do to slow its progress and to give cats with the condition a more comfortable life.<\/span><\/p>\n<p><span style=\"font-size: 18pt;\"><strong><span style=\"font-family: georgia,palatino,serif;\">What can behaviorists and cat parents do?<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Whether the symptoms a pet parent might see are caused by aging, dementia or CDS, lifestyle changes can give Finchley an easier life. Behaviorists, too, can help owners make a significant difference in their cat\u2019s quality of life with some simple suggestions:<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">1. Keep the environment accommodating.<\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: georgia,palatino,serif;\">Make litterboxes as accessible as possible. That may mean placing more of them, and buying bigger ones with lower sides. They should be placed where he spends most of his time now. If he forgets to go, periodically take him to the box. Nightlights are a good way to illuminate them.<\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: georgia,palatino,serif;\">Any changes in the household should be made slowly\u2014change itself is hard to accept when a cat is at her best, but with CDS, it\u2019s harder. Try to avoid making big changes like rearranging the furniture, which can be very confusing.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">2. Keep Finchley alert and active.<\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: georgia,palatino,serif;\">If there are changes in his sleep cycles, suggest keeping him awake as much as reasonable during the day, so he sleeps during the night. A calm, regular everyday routine helps reinforce his sense of place and decreases that \u201clost\u201d feeling.<\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: georgia,palatino,serif;\">Encourage activities that provide lots of mental and physical stimulation. Add more exercise; interactive toys like Da Bird, the Neko Flies or the Cat Dancer; brushing; food-puzzle and \u201cactivity\u201d toys and boxes; even teaching Finchley tricks. Cats with active minds have more nerve connections, which mean extra brain function.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">3. Manage behavior problems compassionately.<\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: georgia,palatino,serif;\">No punishment! Don\u2019t yell or use aversives. That shouldn\u2019t happen anyway, of course, but remind everyone\u2014including yourself\u2014that Finchley can\u2019t help it. The time you spend together should be loving and rewarding. That strengthens your bond and hugely improves his quality of life. He deserves that.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">4. Consider a change in diet, adding supplements, or prescription medication.<\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: georgia,palatino,serif;\">Veterinarians often suggest a change in diet: increasing essential fatty acids, keeping carbs down, and adding vitamin E. Research in humans and dogs has shown that diets enriched with antioxidants, as well, reduced amyloid production,and improved cognitive function. These benefits are presumed to carry over in cats.<\/span><\/p>\n<p style=\"padding-left: 30px;\"><span style=\"font-family: georgia,palatino,serif;\">However, increasing vitamins, potassium and manganese hasn\u2019t been proven to help. Nor have gingko biloba or SAM-e. There is no firm data that indicates any supplements actively work.<\/span><\/p>\n<p><span style=\"font-size: 18pt;\"><strong><span style=\"font-family: georgia,palatino,serif;\">What about medication? The following meds are often suggested:<\/span><\/strong><\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Selegiline (l-deprenyl) is sometimes used in people with Parkinson\u2019s and Alzheimer\u2019s, as it can increase the concentration of dopamine, needed for cognitive processes. With dogs, success has been hard to monitor, and results are mixed.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Minocycline, an anti-inflammatory antibiotic which decreases nerve degeneration, is also often recommended for feline CDS.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Additionally, a veterinarian may prescribe an anti-anxiety drug, such as fluoxetine (Prozac), to ease some of the more alarming signs of cognitive dysfunction, but again, there is scant evidence it will be effective. \u201cI have not had good success with this drug , and have not used it in cats,\u201d says neurologist Plummer.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">No drugs are specifically licensed in North America for the treatment of cognitive dysfunction in cats. Medications tried on cats have only been cleared for use in dogs.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">So, the \u201cskim milk\u201d advice: use dietary supplements and increased environmental enrichment, and perhaps, just perhaps, we can keep feline cognitive dysfunction at bay. A little. Sounds good. Does it all slow the progression of CDS? We have no proof any of it does. There are, after all, no diagnostic tests. No brain mapping.<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">Last night I watched Grace, usually curled up with me, wander around the bedroom. This was new. Cats usually have a good saunter around to see what, if anything, has changed. But this was, indeed, aimless. I lay there, with vision blurred, cheek wet, wondering if this was the beginning\u2026<\/span><\/p>\n<p><span style=\"font-family: georgia,palatino,serif;\">We owe it to our beloved pets to support them, for as long as we possibly can, for as long as our fur-kids have a decent quality of life, and knowing somehow, some day, when loving means to continue, or to let them go. (Oh, why isn\u2019t there a damned tissue when you need one?)<\/span><\/p>\n<p><em><span style=\"font-family: georgia,palatino,serif;\">Jane Ehrlich is a feline behaviorist with over 28 years\u2019 experience working with cats. She lives in Phoenix with three rescue cats, and runs Cattitude Feline Behavior (<span style=\"color: #0000ff;\"><a href=\"http:\/\/www.cattitudebehavior.com\">CattitudeBehavior.com<\/a><\/span>).<\/span><\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Published August 21, 2012, The IAABC Journal (International Association Of Animal Behavioral Consultants) The joys of keeping our cats indoors with plenty of environmental enrichment, good food, health care and an enormous amount of love and respect are all well-documented: <span class=\"excerpt-dots\">&hellip;<\/span> <a class=\"more-link\" href=\"https:\/\/www.cattitudebehavior.com\/index.php\/2017\/07\/28\/feline-cognitive-dysfunction\/\"><span class=\"more-msg\">Continue reading &rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20,19,48],"tags":[15,11,17,16],"class_list":["post-421","post","type-post","status-publish","format-standard","hentry","category-cat-dementia-alzheimers","category-cat-health","category-iaabc","tag-behavior","tag-cats","tag-feline-cognitive-dysfunction","tag-medical-conditions"],"_links":{"self":[{"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/posts\/421","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/comments?post=421"}],"version-history":[{"count":4,"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/posts\/421\/revisions"}],"predecessor-version":[{"id":1893,"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/posts\/421\/revisions\/1893"}],"wp:attachment":[{"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/media?parent=421"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/categories?post=421"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.cattitudebehavior.com\/index.php\/wp-json\/wp\/v2\/tags?post=421"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}